Doctors Struggle to Treat Gram-Negative Bacterial Infections
...Acinetobacter baumannii.
The germ is one of a category of bacteria that by some estimates are already killing tens of thousands of hospital patients each year. While the organisms do not receive as much attention as the one known as MRSA -- for methicillin-resistant Staphylococcus aureus -- some infectious-disease specialists say they could emerge as a bigger threat.
That is because there are several drugs, including some approved in the last few years, that can treat MRSA. But for a combination of business reasons and scientific challenges, the pharmaceuticals industry is pursuing very few drugs for Acinetobacter and other organisms of its type, known as Gram-negative bacteria. Meanwhile, the germs are evolving and becoming ever more immune to existing antibiotics.
"In many respects it%u2019s far worse than MRSA," said Dr. Louis B. Rice, an infectious-disease specialist at the Louis Stokes Cleveland V.A. Medical Center and at Case Western Reserve University. "There are strains out there, and they are becoming more and more common, that are resistant to virtually every antibiotic we have."
The bacteria, classified as Gram-negative because of their reaction to the so-called Gram stain test, can cause severe pneumonia and infections of the urinary tract, bloodstream and other parts of the body. Their cell structure makes them more difficult to attack with antibiotics than Gram-positive organisms like MRSA.
Bold above, added by me.
Cool. Big pharma can't make big money by fighting Gram-Negative infections.
So, they don't.
Read more about this at the NYTimes.com link above.
No comments:
Post a Comment